Xiaozhen Li1, Zhengguang Chen2
1Radiology, Peking Union Medical College
Hospital, Beijing, China; 2Radiology, First Hospital of Tsinghua,
Beijing, China
Conventional
neuroimaging cannot help us either to differentiate between chronic and acute
brain lesions or to improve in our understanding of systemic lupus erythematosus
(SLE) pathogenesis because of the high probability of a Neuropsychiatric SLE
(NPSLE) event. The fMRI including DTI, which demonstrates the tissue water
mobility in brain tissue, and flow-sensitive alternating inversion recovery
(FAIR), which reveals the relative cerebral blood flow, may help to further
assess the possible abnormality in neuronal and neural vascular reactivity in
NPSLE. In this study we found in combination of ADC, FA, rCBF have high
sensitivity in detecting earlier pathologic changes in NPSLE.