Quan Jiang1,2, Guang Liang Ding, Siamak
Pourabdollah-Nejad1, Chang Sheng Qu3, Asim Mahmood3,
Li Zhang1, Zheng Gang Zhang1, Jiani Hu4,
Nassan Bagher-Ebadian1, James R. Ewing1, Michael Chopp1,2
1Neurology, Henry Ford Health System,
Detroit, MI, United States; 2Physics, Oakland University,
Rochester, MI, United States; 3Neurosurgery, Henry Ford Health
System, Detroit, MI, United States; 4MR Center, Wayne State
University, Detroit, MI, United States
We
investigated cell-based treatment induced white matter remodeling after
traumatic brain injury (TBI) using Gaussian, q-ball, standard deviation (SD)
DTI, and immuno-histochemistry staining. We demonstrate that in brain tissue
with a preponderance of single oriented fibers, Gaussian DTI can correctly
identify white matter reorganization and detect changes of axonal orientation
in the boundary recovery region after TBI. However, SD and q-ball need to be
employed to measure WM reorganization if substantial fiber crossing is
present in the recovery tissue. Our data suggest that combination SD and FA
data may provide information about the stage of white matter remodeling after
TBI.