Kwangyeol Baek1,2, Katherina
Eikermann_Haerter3, Woo Shim1,2, Cenk Ayata3,
Guangping Dai1, Jeong Kon Kim4, Bruce R. Rosen1,
Jaeseung Jeong2, Young Ro Kim1
1Radiology, Athinoula A. Martinos
Center for Biomedical Imaging, Charlestown, MA, United States; 2Bio
and Brain Engineering, KAIST, Daejeon, Korea, Republic of; 3Radiology,
Massachusetts General Hospital, Charlestown, MA, United States; 4Radiology,
Asan Medical Center, Seoul, Korea, Republic of
Spreading
depression (SD) is a propagating wave of cellular depolarization, and
implicated in pathophysiology of migraine and peri-infarct depolarization. In
last decade, MRI started to be used for non-invasive imaging of SD, but not
much is known about the neurovascular coupling in SD, especially for
subcortical regions. We investigated CBV changes induced by SD in cortical
and subcortical regions using intravenous contrast agent. We observed marked
CBV increase (up to 20%) in cortex, striatum, and hippocampus, but not in
thalamus. The CBV response gradually reached peak ~5 min after the neuronal
depolarization, suggesting neurovascular coupling is largely modified in SD.