Abu-Bakar-Md-Ali Asad1, Kai-Hsiang Chuang1
1Laboratory of Molecular Imaging,
Singapore Bioimaging Consortium, Agency for Science, Technology and Research,
Singapore, Singapore
We
compared the difference in Mn uptake and retention rates at various brain
regions after systemic administration of MnCl2. By estimating Mn concentration
with the change in T1 relaxation rate (ΔR1), it was observed that
different brain regions have considerable difference in the time-to-peak and
bioelimination rate of Mn. The ΔR1-time course was fitted to a gamma
variate model which showed reasonable fit and provides estimation of
time-to-peak, peak value and half-life. The olfactory bulb reached the peak
earliest and highest, while regions like thalamus reached peak at day 2.
Olfactory bulb had fastest clearance with a half-life of 6.6 days, and
cerebellum had longer half-life of 11.5 days. This method can allow better
estimate of the uptake and retention and can be used to maximize tissue
contrasts or applied to studying of transporter mechanism in animal models.