Joong Hee Kim1, Anne H. Cross2, Sheng-Kwei Song3
1Radiology, Washington University , St. Louis, MO, United States; 2Neurology, Washington University, St. Louis, MO, United States; 3Radiology, Washington University, St. Louis, MO, United States
Diffusion tensor imaging (DTI) was used to examine the spinal cords of mice with experimental autoimmune encephalomyelitis (EAE), an animal model of Multiple Sclerosis. Compared to age-matched controls, EAE-affected mice exhibited a statistically significant decrease in axial diffusivity in spinal cord white matter. The decrease of axial diffusivity was parallel to disease severity examined by clinical scoring of EAE mice. The axial diffusivity threshold analysis on EAE-affected mice enabled quantifying the extent of abnormal or damaged axons, which correlated with four independent neurological assessments.