Study of the Pathophyisology of Demyelination in an Experimental Model: Correlation of Lesion Volume with T2, Apparent Diffusion Coefficient (ADC) and Fractional Anisotropy (FA)

Krithika Balasubramanian¹, Uma Sharma¹, Senthil S. Kumaran¹, Naranamangalam R. Jagannathan¹

Evaluation of variation in T2, ADC and FA with the lesion volume at various stages of de- and re-myelination in a demyelinating rat model was carried out at 4.7 T. During demyelination lesion size, T2 and ADC increased while FA decreased indicating loss of myelin, while these values were reversed during remyelination. A strong positive correlation was observed between lesion volume and T2 and between lesion volume and ADC, while FA showed strong negative correlation. Our data thus indicated the potential of parameters in characterizing the various stages of the de- and re-myelination thus providing useful information on its pathophysiology.