Daniel Coman1,2, Robin A. de Graaf3, Douglas L. Rothman, 23, Fahmeed Hyder, 23
1Diagnostic Radiology, Yale University, New Haven, CT, United States; 2Quantitative Neuroscience with Magnetic Resonance (QNMR), Yale University, New Haven, CT, United States; 3Diagnostic Radiology and Biomedical Engineering, Yale University, New Haven, CT, United States
Biosensor Imaging of Redundant Deviation in Shifts (BIRDS) is used for pH/temperature mapping in rat brain. The BIRDS method relies on strong dependence of non-exchangeable protons from thulium based macrocyclics, e.g., TmDOTP5- and TmDOTMA-, for temperature and pH. Although high speed 2D CSI allows ~10μL voxels in rats cerebral cortex within 5 minutes, many applications require whole brain coverage and high spatiotemporal resolution. Here we demonstrate a 3D CSI of a 22.214.171.124 cm field-of-view with 1μL voxels in 5 minutes using reduced k-space spherical encoding, which represents an order of magnitude sensitivity enhancement from the 2D CSI data acquisition.