Daniel Coman1,2, Robin A. de Graaf3,
Douglas L. Rothman, 23, Fahmeed Hyder, 23
1Diagnostic Radiology, Yale University,
New Haven, CT, United States; 2Quantitative Neuroscience with
Magnetic Resonance (QNMR), Yale University, New Haven, CT, United States; 3Diagnostic
Radiology and Biomedical Engineering, Yale University, New Haven, CT, United
States
Biosensor Imaging of Redundant Deviation in
Shifts (BIRDS) is used for
pH/temperature mapping in rat brain. The BIRDS method relies on strong
dependence of non-exchangeable protons from thulium based macrocyclics, e.g.,
TmDOTP5- and TmDOTMA-, for temperature and pH. Although
high speed 2D CSI allows ~10μL voxels in rats cerebral cortex within 5
minutes, many applications require whole brain coverage and high
spatiotemporal resolution. Here we demonstrate a 3D CSI of a 2.52.52.5 cm
field-of-view with 1μL voxels in 5 minutes using reduced k-space
spherical encoding, which represents an order of magnitude sensitivity
enhancement from the 2D CSI data acquisition.