Colin Morehouse Carpenter1,2, Rebecca
Rakow-Penner3, Shudong Jiang2, Brian William Pogue2,
Keith David Paulsen2, Gary H. Glover3
1Radiation Oncology, Stanford
University School of Medicine, Stanford, CA, United States; 2Thayer
School of Engineering at Dartmouth, Hanover, NH, United States; 3Radiology,
Stanford University School of Medicine, Stanford, CA, United States
BOLD
response in the breast was measured concurrently with MR-guided diffuse
optical tomography (MRg-DOT) in 11 healthy volunteers during inspired gas
changes. This approach utilized optical imaging to quantitatively identify
the independent effects of oxy- and deoxyhemoglobin. A key factor in this study was
characterization of the background physiological noise variations in
individual subjects, which was measured via optical imaging during air
breathing. The results from this work indicate that BOLD and
optically-determined deoxyhemoglobin signals correlate significantly in the
breast during an oxygen/carbogen respiratory stimulus, as long as only
subjects that exhibit a significant response are included.