Colin Morehouse Carpenter1,2, Rebecca Rakow-Penner3, Shudong Jiang2, Brian William Pogue2, Keith David Paulsen2, Gary H. Glover3
1Radiation Oncology, Stanford University School of Medicine, Stanford, CA, United States; 2Thayer School of Engineering at Dartmouth, Hanover, NH, United States; 3Radiology, Stanford University School of Medicine, Stanford, CA, United States
BOLD response in the breast was measured concurrently with MR-guided diffuse optical tomography (MRg-DOT) in 11 healthy volunteers during inspired gas changes. This approach utilized optical imaging to quantitatively identify the independent effects of oxy- and deoxyhemoglobin. A key factor in this study was characterization of the background physiological noise variations in individual subjects, which was measured via optical imaging during air breathing. The results from this work indicate that BOLD and optically-determined deoxyhemoglobin signals correlate significantly in the breast during an oxygen/carbogen respiratory stimulus, as long as only subjects that exhibit a significant response are included.