Sungheon Kim1, Linda Moy1, Malcolm C. Pike2, Anne Zeleniuch-Jacquotte3, Tess Clendenen4
1Center for Biomedical Imaging, Radiology, NYU School of Medicine, New York, NY, United States; 2Preventive Medicine, USC Keck School of Medicine, Los Angeles, CA, United States; 3Environmental Medicine, NYU School of Medicine, New York, NY, United States; 4Epidemiology, NYU School of Medicine, New York, NY, United States
The purpose of this study was to develop a multiparametric MRI method to investigate magnitude and timing of various breast changes during the menstrual cycle. Five healthy premenopausal women were scanned once a week for four weeks. T2, ADC, and magnetization transfer rate were measured. T2 gradually increased throughout the cycle and was 5% higher in the menstrual phase than the follicular phase. In contrast, the median ADC was highest in the luteal phase (15% greater than the follicular phase) and began to decline during menses. The MTR was about 4% lower in the menstrual phase than the follicular phase.