Francesco Molinari1,2, Grzegorz Bauman3, Monika Eichinger2, Bernhard Geiger4, Lorenzo Bonomo1, Hans-Ulrich Kauczor5, Michael Puderbach2
1Department of Bioimaging and Radiological Sciences, Catholic University of Rome, Rome, Italy; 2Department of Radiology, German Cancer Research Center, Heidelberg, Germany; 3Department of Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany; 4Siemens Corporate Research, Princeton, United States; 5Department of Radiology, University of Heidelberg, Heidelberg, Germany
In oxygen-enhanced MRI, lung signal is measured repeatedly during different breathing cycles. Inconsistencies of respiratory phase may hamper the quality of the parametric O2-maps. In this study, fully automatic non-rigid registration was assessed as a postprocessing method to improve the quality of O2-MRI of the lung. This post-processing technique reduced spatial misalignment among images and signal variability within the lung. O2-induced signal enhancement was not influenced by image registration. Spatial heterogeneity of parametric O2-maps decreased significantly. As such, fully automatic non-rigid registration appears suitable for improving the quality of multislice O2-MRI of the lung.