Yi Wang1, Frank H. Miller1,
Robert McCarthy, Zongming E. Chen, Laura Sternick, Daniel Ganger, Richard
Ehman2, Reed Omary1, Josh Levitsky, Bradley D. Bolster,
Jr. 3, Saurabh Shah3, Sven Zuehlsdorff3,
Paul Nikolaidis1, Vahid Yaghmai1
1Radiology, Northwestern University
Feinberg School of Medicine, Chicago, IL, United States; 2Mayo
Clinic; 3Siemens Healthcare
We
proposed to evaluate the capability of MRE in detecting and distinguishing
patients with inflammation and without fibrosis from patients without
inflammation and fibrosis, and with various stages of fibrosis based on
histopathologic analyses. Liver tissue with inflammation and without fibrosis
can be seen with mildly elevated stiffness value on MRE, which was
significantly higher than those that lack inflammation and fibrosis. Both
mild hepatic fibrosis and inflammation was associated with mild elevation of
stiffness, but a significant difference was not observed. Furthermore, tissue
with moderate fibrosis and advanced fibrosis to cirrhosis showed significant
increased stiffness values on MRE.