Keiko Miyazaki1, Matthew R. Orton1,
James A. d'Arcy1, Val Lewington2, Dow-Mu Koh3,
Martin O. Leach1, David J. Collins1
1CR-UK and EPSRC Cancer Imaging Centre,
The Institute of Cancer Research and Royal Marsden Hospital, Sutton, Surrey,
United Kingdom; 2Department of Nuclear Medicine, Royal Marsden NHS
Foundation Trust, Sutton, Surrey, United Kingdom; 3Department of
Radiology, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom
Dynamic
contrast-enhanced (DCE-) MRI is a technique that enables non-invasive
interrogation of tissue microvasculature environment. Different analysis
approaches can be taken to quantify arterial and portal-venous hepatic
perfusion from liver DCE-MRI data. In this study, two slope-ratio methods
were used to quantify arterial and portal-venous perfusion from clinical MR
data. Comparisons were made with perfusion quantified using a dual-input
single compartment model. Perfusion quantified using the slope-ratio methods
were found to be lower than those quantified using the dual-input model. High
correlations were observed between the two approaches, especially in the
estimates of arterial perfusion.