Edmund Mark Godfrey1, Anant S. Krishnan1, Susan E. Davies2, Nyree M. Griffin3, Graeme J. Alexander4, Mike E. Allison4, Alexander E. Gimson4, William H. Griffiths4, David J. Lomas1
1Department of Radiology, Addenbrooke's Hospital, Cambridge, Cambridgeshire, United Kingdom; 2Department of Histopathology, Addenbrooke's Hospital, Cambridge, Cambridgeshire, United Kingdom; 3Department of Radiology, St Thomas' Hospital, London; 4Department of Hepatology, Addenbrooke's Hospital, Cambridge, Cambridgeshire, United Kingdom
Standard imaging techniques are insensitive to liver fibrosis. Current clinical assessment of liver fibrosis requires a biopsy, which risks complications and sampling error. This work describes our experience with 2 new MR techniques: MR elastography and 31P spectroscopy. MR elastography was found to correlate with histological grade of fibrosis in contrast to 31P PME/PDE ratio. Our findings do not correlate with previous work. This may be because histological grade in our study was based on the original report, rather than review of the biopsy material. We plan to repeat the analysis of our results with this data.