Elisa Placidi1, C. L. Hoad1, L. Marciani2, R. C. Spiller2, P. A. Gowland1
1SPMMRC, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom; 2Nottingham Digestive Diseases Centre Biomedical Research Unit, University of Nottingham, Nottingham, United Kingdom
MRI was used to investigate the colonic response to two contrasting test meals: a readily absorbable glucose drink (control) and a non absorbable mannitol drink, which acts as a model of acute diarrhoeal disease. Eight healthy volunteers were imaged on a 1.5 T Philips Achieva scanner with several sequences up to 8 hours after the drink, to assess changes in the ascending colon in terms of water content, volume, and image signal intensity. Differences between the two conditions have been quantified. A scoring system based on subjective assessment of colonic contents has also been developed.