Eleanor F. Cox1, Michael Mellows2,
Susan E. Pritchard1, Mahamoud Hussein1, Caroline L.
Hoad1, Carolyn Costigan3, Luca Marciani2,
Robin C. Spiller2, Penny A. Gowland1
1SPMMRC, Physics & Astronomy,
University of Nottingham, Nottingham, Nottinghamshire, United Kingdom; 2Nottingham
Digestive Diseases Centre, NIHR BRU, Nottingham University Hospitals,
Nottingham, United Kingdom; 3Brain & Body Centre, University
of Nottingham, Nottingham, United Kingdom
The
effect of a high fat (HF) meal and an equicaloric high carbohydrate (HC) meal
on satiety, gastric volumes, small bowel water content (SBWC) and gallbladder
contraction (as a marker of CCK release) was investigated using MRI. The HF
meal resulted in increased fullness and decreased hunger and appetite
compared with the HC meal. Gastric emptying was initially faster for the HF
meal. After 90 minutes, SBWC was greater after the HF meal than after the HC
meal. This delayed increase may reflect delayed emptying of fat which
stimulates pancreatic secretions.