Logan Dance1, Andrew Wentland2, Nathan Artz2, Sean Fain1,2, Arjang Djamali3, Elizabeth Sadowski1
1Radiology, University of Wisconsin, Madison, WI, United States; 2Medical Physics, University of Wisconsin, Madison, WI, United States; 3Nephrology, University of Wisconsin, Madison, WI, United States
Blood oxygen level dependent (BOLD) and arterial spin labeling (ASL) MR imaging can analyze the drug-specific effects of anesthetics on regional perfusion. Conflicting data currently exists regarding isoflurane's effect on renal perfusion. Using a swine model, we found that isoflurane decreased renal perfusion (ASL; microspheres) and renal oxygen bioavailability (BOLD MR) when compared to propofol. Isoflurane also caused a significant increase in heart rate and decrease in mean arterial pressure, compared to propofol. These effects should be considered when designing kidney perfusion studies.