Akira Yamamoto1, Jeff Lei Zhang1, Henry Rusinek1, Hersh Chandarana1, James Babb1, Thomas Diflo2, Devon John2, Judith Benstein3, Pierre H. Vivier1, David Stoffel1, Vivian S. Lee1
1Radiology, New York University School of Medicine, New York, United States; 2Surgery, New York University School of Medicine, New York, United States; 3Medicine, New York University School of Medicine, New York, United States
60 patients (31 clinically normal-functioning transplanted kidney, 29 acute dysfunction transplanted kidney) were examined to assess quantitative low-dose 3D MR renography to diagnose acute transplant dysfunction. Acute rejection showed higher ratio of vascular mean transit time to whole kidney (MTT-A/K) and lower tubular transit time fraction (MTT-T/K) compared to ATN. In particular, the diagnostic test that classified patients as acute rejection when MTT-A/K 9.0% and as ATN otherwise achieved 100% diagnostic accuracy. Our method of MR renography is promising for the diagnosis of acute transplant renal dysfunction and can be performed as a component of routine anatomic imaging of the transplanted kidney.