Thomas Kwee1, Inge Ludwig2, Cuno
Uiterwaal3, Henritte Quarles van Ufford1, Marc
Bierings4, Rob Fijnheer5, Taro Takahara1,
Rutger-Jan Nievelstein1
1Department of Radiology, University
Medical Center Utrecht, Utrecht, Netherlands; 2Department of Hematology,
University Medical Center Utrecht, Utrecht, Netherlands; 3Julius
Center for Health Sciences and Primary Care, University Medical Center
Utrecht, Utrecht, Netherlands; 4Department of Pediatric
Hematology, University Medical Center Utrecht, Utrecht, Netherlands; 5Department
of Hematology, Meander Medical Center, Amersfoort, Netherlands
This
study aimed to investigate whether apparent diffusion coefficient (ADC)
measurements allow discriminating normal lymph nodes from lymphomatous lymph
nodes, and indolent lymphomas from aggressive lymphomas in patients with
non-Hodgkin lymphoma (NHL). To that end, 18 healthy volunteers and 22
patients with newly diagnosed NHL (indolent: n=9; aggressive: n=13)
prospectively underwent diffusion-weighted imaging at 1.5 T. Our results
suggest that ADC measurements may be a highly specific method for
discriminating normal lymph nodes from lymphomatous lymph nodes in patients
with NHL. However, ADC measurements appear to be of no utility in
differentiating indolent from aggressive lymphomas.