Nina Tunariu1, James A. d'Arcy, Veronica A. Morgan1, Michael Germuska, Catherine G. Simpkin, Sharon L. Giles2, David J. Collins, Nandita M. deSouza
1 CR-UK and EPSRC Cancer Imaging Centre, Institute of Cancer Research and Royal Marsden Hospital, Sutton, Surrey, United Kingdom; 2CR-UK and EPSRC Cancer Imaging Centre, Institute of Cancer Research and Royal Marsden Hospital, United Kingdom
A major challenge for implementing diffusion-weighted magnetic resonance imaging (DW-MRI) as tumour response biomarker in multicentre clinical trials is in measuring changes in individual patients reliably and reproducibly. The delineation of the region of interest (ROI) has a great impact on final reproducibility. This study compares ADC values obtained using in-house computer ROI drawing software (Diffusion View) to segment tumour with those obtained from a manual drawing technique. Computer generated ROIs have the advantage of less variability, operator independence and significant time saving and support the feasibility of use of automated DWI measurements in clinical trials.