Gavin Hamilton1, Michael S. Middleton1, Takeshi Yokoo1, Mark Bydder1, Irene W. Mwangi1, Michael E. Schroeder1, Claude B. Sirlin1
1Department of Radiology, University of California, San Diego, San Diego, CA, United States
Accurate proton (1H) MRS fat quantification of liver fat requires determination of signal from fat peaks that are near or under the water peak. A theoretical triglyceride model was developed to characterize the liver fat spectrum, using number of -CH=CH- and -CH=CH-CH2-CH=CH- bonds, and average fatty acid chain length. In vivo, the relative areas of the different fat peaks are strongly correlated suggesting the fat profile is uniform regardless of the level of fat deposition in the liver. The model gives that 8.6% of the total liver fat underlies the water peak.