Jerry S. Cheung1,2, Shu Juan Fan1,2, Darwin Shan Gao1,2, Kannie W.Y. Chan1,2, April M. Chow1,2, Kwan Man3, Ed X. Wu1,2
1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Pokfulam, Hong Kong SAR, China; 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam, Hong Kong SAR, China; 3Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
Carbon tetrachloride (CCl4) intoxication is a well-characterized, reproducible and the most commonly used experimental model of liver fibrosis. Proton magnetic resonance spectroscopy (1H MRS) can provide insights into in vivo liver metabolism noninvasively, yet detailed in vivo MRS study of CCl4-induced liver fibrosis model has been limited. The aim of this study was to characterize early metabolic changes in CCl4-induced liver fibrosis in rodents by means of single-voxel 1H MRS. Our experimental results demonstrated that 1H MRS at high field may be valuable in characterizing metabolic changes in liver, in particular those related to lipid and glutamine metabolism, after CCl4 insult.