Luminita Alina Tudorica1, Stephanie Hemmingson1, Karen Oh1, Arpana Naik1, Sunitha Thakur2, Elizabeth A. Morris2, Mark Kettler1, Ian J. Tagge1, Jason A. Koutcher2, Charles S. Springer1, Wei Huang1
1Oregon Health & Science University, Portland, OR, United States; 2Memorial Sloan Kettering Cancer Center, New York, NY, United States
Three of 28 core needle biopsy-proven high-risk atypical breast lesions were upgraded to malignancies following surgical excisions as standard care. Correlations with pre-biopsy quantitative DCE-MRI results show that the Shutter-Speed Model (SSM) analyses of DCE-MRI data discriminate the atypical lesions between those completely benign and those containing malignancies with high accuracy. SSM DCE-MRI can potentially be used to reduce unnecessary surgeries of atypical lesions.