Associations Between MR Derived Vascular, Shape and Texture Parameters with Histological Descriptors

Martin D. Pickles¹, Peter Gibbs¹, Martin Lowry¹, Lindsay W. Turnbull¹

Features such as shape (round, irregular), enhancement (homogeneous, heterogeneous), and kinetic curve assessment (persistent, plateau and washout) have been used to aid in the classification of breast lesions. These features may also help to highlight patients who subsequently have a reduced overall and disease free survival intervals. The aim of this work was to determine if there were any associations between pre-treatment MR derived quantitative descriptors (shape, enhancement and kinetic curve assessment) and traditional prognostic indicators. This work has demonstrated that when comparing traditional prognostic indicators (nodal hormonal status) significant differences in shape, texture and vascular kinetics are apparent.