Hon Yu1, Jack Hsu1, Ke Nie1,
Muqing Lin1, Siwa Chan2, Jeon-Hor Chen1,2,
Rita S. Mehta3, Orhan Nalcioglu1, Min-Ying Lydia Su1
1Center for Functional Onco-Imaging,
University of California, Irvine, CA, United States; 2Department
of Radiology, China Medical University Hospital, Taichung, Taiwan; 3Department
of Medicine, University of California, Irvine, CA, United States
The
suggested association between the chemotherapy-induced ovarian suppression
and a positive prognostic impact for more favorable treatment outcome in
pre-menopausal women with breast cancer was investigated. Using the
enhancement values of DCE-MRI measured from the fibroglandular tissue of
contralateral normal breast as a measure of ovarian suppression effect, our
retrospective study indicates a possible prognostic value of such measurement
via an association between an early onset of chemotherapy-induced ovarian
suppression and positive treatment outcomes among the younger group of women
(< 55 yr.). The observed association between early onset of reduced
perfusion and poor treatment outcome among the older group of women ( 55
yr.) may represent an additional potential of the prognostic value in
treatment-induced effects measured from the normal breast.