Naranamangalam R. Jagannathan1, Rani G. Sah1, Uma Sharma1, Rajinder Parshad2
1Department of NMR & MRI Facility, All India Institute of Medical Sciences, New Delhi, Delhi, India; 2Department of Surgery, All India Institute of Medical Sciences, New Delhi, Delhi, India
The tCho concentration and tumor volume were calculated using in-vivo MRS and MRI in estrogen positive and negative patients (n=46) with confirmed invasive ductal carcinoma at 1.5 T. The tumor volume for the estrogen positive patients was (33.57 45.7) significantly higher (p=0.03) compared to estrogen negative patients (67.2 60.8). However, the tCho concentration was similar in estrogen positive (4.2 2.3 mmol/kg) and estrogen negative patients (4.1 3.5) mmol/kg. The increase in the tumor volume may be attributed to the higher microvessels density in ER negative cancer patients.