Giuseppe Petralia1, Paul Summers1, Luke Bonello1, Stefano Viotti1, Roberto Di Filippi1, Laura Traviani2, Maria Giulia Zampino3, Dow-Mu Koh4, Maria Cristina Leonardi5, Antonio Chiappa6, Massimo Bellomi1
1Radiology, Istituto Europeo di Oncologia, Milan, Lombardia, Italy; 2Nuclear Medicine, Istituto Europeo di Oncologia, Milano, Italy; 3Medical Care Unit, Department of Medicine, Istituto Europeo di Oncologia, Milan, Lombardia, Italy; 4Radiology, Royal Marsden Hospital, Sutton, United Kingdom; 5Radiotherapy, Istituto Europeo di Oncologia, Milan, Lombardia, Italy; 6General and Laparoscopic Surgery, Istituto Europeo di Oncologia, Milan, Lombardia, Italy
Functional imaging techniques have potential in monitoring neoadjuvant chemoradiation therapy and predicting therapy outcome in locally advanced rectal cancers. We compared four different functional modalities (DCE-MR, DW-MR,CTp and PET) in patients with locally advanced rectal cancer who underwent imaging with all modalities before and after neoadjuvant treatment. From our small patient population we observed a correlation between Kep and PS, both estimates of capillary permeability (R=0.93), and a trend to correlation between Ktrans and PS (R= 0.47), whereas negative correlations were observed between Ktrans and SUV (R=-0.78), Ve and SUV (R=-0.86), and a negative trend for ADC and SUV (R=-0.50).