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Abstract #4779

T2-Weighted MR Imaging Combined with Diffusion Weighted MR Imaging for Selection of True Active Surveillance Patients Based on Stage and Gleason Score Criteria: A Retrospective Multireader Study.

Caroline Hoeks1, Pieter Vos1, Diederik Somford2, Derya Yakar1, Thomas Hambrock1, Stijn Heijmink1, Jurgen Futterer1, Henk Vergunst3, Christina Hulsbergen-van de Kaa4, Fred Witjes2, Henkjan Huisman1, Jelle Barentsz1

1Department of Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands; 2Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands; 3Department of Urology, Canisius Wilhelmina Hospital, Nijmegen, Gelderland, Netherlands; 4Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands


Problem Undersampling of prostate cancer can lead to incorrect surveillance (AS) patient selection. Aim: to determine if T2-weighted (T2w) MRI and diffusion weighted MRI (DWI) could contribute in AS patient selection by comparing radiologist reading of stage and Gleason score(GS) to prostatectomy. Methods Twelve prostatectomy patients were retrospectively selected by biopsy criteria and a performed 3T MRI preprostatectomy. Four radiologists scored T2w-MRI and T2w-MRI in combination with DWI. Results AUC values for T2w-MRI prediction of AS patients varied from 0,812 for inexperienced reader to 0,812-1,0 for experienced readers. Conclusion T2w-MRI could be of additional value in AS patient selection.