Dmitri Artemov1, Kristy L. Weber2, Yoshinori Kato1, Wenlian Zhu1, Zaver M. Bhujwalla1
1JHU ICMIC Program, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States; 2Department of Orthopedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, United States
Metastasis is the leading cause of mortality from cancer. For several cancers, the bone is a major site of bulk disease from metastasis. While multimodality imaging of subcutaneous preclinical tumor models are becoming fairly routine, the application of multi-modality imaging to bone-metastasis models is a challenge. However, multi-modality imaging of such models can provide a wealth of information on the microenvironment, vasculature, and metabolism of bone metastasis that can used to improve treatment outcome and identify new strategies for treatment. Here we present multi-modal imaging characterization of a well-established bone metastasis model.