Jamu K. Alford1, Blaine A. Chronik1
1Physics and Astronomy, The University of Western Ontario, London, ON, Canada
Delta relaxation enhanced magnetic resonance (dreMR) is an emerging method for performing molecular imaging, which utilizes a removable electromagnetic coil to modify the strength of the main magnetic field during an MRI pulse sequence. The purpose of this field-cycling method is to acquire information about the binding state of targeted contrast agents that is not obtainable with static-field MRI methods. This work describes a method for advancing dreMR from qualitative imaging to quantitative measurement of contrast agent binding. By measuring the concentration of bound agent, the corresponding concentration of the target molecule can determined.