Christina Louise Tosti1, Boguslaw S. Wojczyk2, Sujit S. Sheth2, Daniel Kim3, Haiying Tang2, Jens H. Jensen3, Gary M. Brittenham2, Truman R. Brown2
1The Ohio State University, Columbus, OH, United States; 2Columbia University, New York, NY, United States; 3New York University, New York, NY, United States
A theoretical MR model has been proposed that separately quantifies dispersed (soluble, ferritin-like) and aggregated (insoluble, hemosiderin-like) iron by distinguishing their effects on R2 relaxation curves. In this study, we examine human liver explants with this non-invasive MR iron measurement technique. We compare the results of iron quantification using this model to the tissue concentrations of ferritin and hemosiderin iron determined by biochemical analysis.