Andrew Walsh1, Marguerite Wieler2, Wayne Martin2, Alan Wilman1
1Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada; 2Division of Adult Neurology, University of Alberta, Edmonton, Alberta, Canada
We examined the effectiveness of current methods in susceptibility phase imaging of basal ganglia structures using computer simulations and invivo data. The effects of phase filtering reconstruction, slice orientation and ROI selection with comparison to T2* mapping are examined in this study. These investigations showed that measured phase can be substantially influenced by filtering, slice orientation and ROI selection which can confound phase data acquired in cross sectional or longitudinal studies. We have proposed techniques to optimize phase value acquisition for the consistent evaluation of phase in future studies.