Catherine Anusha Mallik1, David Bellis2, David J. Lythgoe1, Rebeca Santamaria-Fernandez2, Gareth J. Barker1
1Centre for Neuroimaging Sciences, Institute of Psychiatry, London, United Kingdom; 2Laboratory of Government Chemists, Teddington, Middlesex, United Kingdom
There is a growing body of MRI research on the effects of abnormal levels of iron in the brain. Validation of quantitative MRI with a phantom of known iron concentrations, is necessary for comparing different MRI measures. To allow cross-validation with Atomic spectrometry (AS) three different AS and MRI compatible phantoms were manufactured using various substrates and concentrations of iron. Phantoms were imaged at 3T with three different iron-sensitive MRI techniques. Imaging results show that a thrombin-fibrinogen gel doped with ferritin is a suitable phantom for both MRI and AS.