Rachel Scheidegger1,2, Elena Vinogradov1,3, David C. Alsop1,3
1Radiology, Beth Israel Deaconess Medical Center, Boston, MA, United States; 2Health Sciences and Technology, Harvard-MIT, Cambridge, MA, United States; 3Radiology, Harvard Medical School, Boston, MA, United States
Amide Proton Transfer (APT) imaging is readily contaminated by asymmetric magnetization transfer and off-resonance errors. Improved robustness to these errors can be achieved using a 3-way subtraction between positive frequency, negative frequency, and combined frequency RF irradiation. Whole slice APT imaging using this approach and without additional acquisitions or corrections is demonstrated in-vivo in human volunteers. The 3-way subtraction was found to significantly improve the APT map homogeneity by reducing susceptibility artifacts and MT asymmetry effects. This method may improve the feasibility of APT imaging for clinical applications.