David Rudko1,2,
Martyn Klassen2, Susan Meakin2, Ravi Menon2
1Department of Physics and Astronomy,
University of Western Ontario, London, Ontario, Canada; 2Robarts
Research Institute, London, Ontario, Canada
In
this study, magnetization transfer (MT) imaging was applied to a mouse model
of GBM at 9.4 T. The goals of this work were: a) to quantify the MT effect in
tumour core and in normal-appearing white matter and (b) to compensate for
susceptibility differences which alter the MT effect at 9.4 T. The MTR in
tumour core was observed to increase significantly from 14.60.5% to
15.30.6% using a field-map based static field correction. Further, the MTR
asymmetry increased in two disparate regions of tumour to values of 15.30.6%
and 13.20.5% relative to in
normal-appearing white matter (MTRasym = 10.71.6%)