Mohammad Haris1, Anup Singh1, Kejia Cai1, Walter R. T. Witschey2, James J. Pilla1, Giovanni Ferrari3, Kevin Koomalsingh3, Robin Hinmon3, Gerald Zsido1, Joseph H. Gorman III3, Robert C. Gorman3, Hari Hariharan1, Ravinder Reddy1
1CMROI, Radiology, University of Pennsylvania, Philadelphia, PA, USA; 2University Hospital Freiburg, Germany; 3Department of Surgery, University of Pennsylvania
We observed the chemical exchange saturation transfer (CEST) effects of water signal in left ventricular infarcted swine heart tissue on 7T clinical scanner. Significantly low CEST contrast was observed in infarcted region compared to non-infarcted region. Low CEST contrast in infarcted region may be due to combined effect from decreased concentration of creatine and low pH. Further characterization of this method on in-vivo animal model of myocardial infarction is in progress.