Claudia Testa1, Caterina Tonon1, David Neil Manners1, Emil Malucelli1, Sara Grandi2, Francesca Sbravati2, Giacomo Faldella2, Gina Ancora2, Raffaele Lodi1
1MR Spectroscopy Unit, Department of Internal Medicine, Aging & Nephrology, University of Bologna, Bologna, Italy; 2Neonatology Unit, Department of Woman, Child & Adolescent Health, University of Bologna, Bologna, Italy
1-MRS and DTI were evaluated in 19 neonates with hypoxic-ischemic encephalopathy after brain cooling. MRS was acquired in the basal ganglia, in white and gray matter; DTI was acquired using 15 gradient directions. Metabolites ratios and concentrations, MD and FA maps were calculated. ROIs were semi-automatically drawn onto each FA and MD map using study specific templates.