Katherine L. Wright1,2, Nicole Seiberlich2,3, John A. Jesberger2, Raymond F. Muzic1,3, Mark A. Griswold1,3, Vikas Gulani2,3
1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA; 2Case Center for Imaging Research, Case Western Reserve University, Cleveland, OH, USA; 3Department of Radiology, University Hospitals, Cleveland, OH, USA
Complete evaluation of both large and small vessel status would typically require two separate contrast enhanced acquisitions: MR angiography and dynamic contrast enhanced (DCE) perfusion. Both the MRA and quantitative DCE perfusion could be obtained simultaneously if a 3D time-resolved contrast enhanced data set could be acquired in a manner that the contrast and spatial/temporal resolution requirements for both exams could be met. This study demonstrates feasibility and repeatability of simultaneous MRA and perfusion (MRAP) with a time resolved MRA acquisition, and initial application for leg angiography and quantitative skeletal muscle perfusion at rest and following a physiological stimulus (exercise).