Wen-ju Pan1, Matthew Magnuson1, Garth Thompson1, Dieter Jaeger2, Shella Keilholz1
1Biomedical Engineering, Emory University/ Georgia Institute of Technology, Atlanta, GA, USA; 2Biology, Emory University, Atlanta, GA, USA
To investigate the neural correspondence of the resting-state BOLD signal fluctuations, simultaneous fMRI and intracortical electrophysiological recording were performed in rat somatosensory cortex under medetomine sedation. During prolonged medetomine administration (1-6 hours), the BOLD signal in the low frequency powers changed from <0.1-Hz to a combination of <0.1 Hz and a localized peak at 0.2-Hz. The intracortical DC/LFPs were correlated to both peaks of the BOLD signal at a time lag of ~2.5 s.