Omer Tal1, Chi Wah Wong2, Valur Olafsson2, Mithun Diwakar1,2, Ming-Xiong Huang2, Thomas T. Liu2
1Department of Bioengineering , University of California - San Diego, La Jolla, CA, USA; 2Department of Radiology, University of California - San Diego, La Jolla, CA, USA
Caffeine has previously been shown to reduce the correlation between resting-state BOLD fluctuations in the motor cortex. However, because of the BOLD signals dependence on both neural and vascular factors, it is not known to what extent these reductions reflect caffeines effect on neural activity as opposed to its effect on the vasculature. In this preliminary study, we use fMRI and magnetoencephalography (MEG) measures to show that caffeine-related decreases in BOLD correlation partially reflect a decrease in neural connectivity.