William D. Rooney1, James R. Pollaro1, Sean C. Forbes2, Dah Jyuu Wang3, Krista Vandenborne2, Glenn A. Walter4
1Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, USA; 2Department of Physical Therapy, University of Florida, Gainesville, FL, USA; 3Department of Radiology, the Children's Hospital of Philadelphia, Philadelphia, PA, USA; 4Department of Physiology & Functional Genomics, University of Florida, Gainesville, FL, USA
Quantitative transverse relaxography (qT2) of proton MR signals has shown sensitivity for pathology of tissues such as muscles in patients with DMD. Standardization across multiple sites, as well as imperfections in multi-echo imaging sequences has led to contamination of the desired primary echo decay. Crushing gradient schemes have been developed, but these can be difficult to implement, especially in multi-slice acquisitions. Extended phase graphs applied during post-processing can isolate the primary echo to improve accuracy of qT2 mapping.