Murat Aksoy1,
Christoph Forman2, Daniel Kopeinigg1, Matus Straka1,
Rafael O'Halloran1, Samantha Holdsworth1, Stefan Skare1,3,
Roland Bammer1
1Radiology,
Stanford University, Stanford, CA, USA; 2Computer Science,
Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany; 3Clinical
Neuroscience, Karolinska Institute, Stockholm, Sweden
Correction of motion is important in diffusion tensor imaging (DTI) due to long acquisition times and the increased likelihood of involuntary motion. Single-shot echo-planar imaging (sshEPI), which is the most frequently used sequence in DTI, allows retrospective motion correction that includes realigning individual diffusion-weighted volumes. However, this correction method is considerably flawed due to its inability to deal with intra-volume motion or spin history effects. In this study, we used a monovision-based optical tracking system to provide real-time motion correction capabilities for sshEPI-DTI. In-vivo results demonstrate that even for single-shot methods, prospective motion correction yields more accurate and precise FA maps and fiber tracts than retrospective motion correction.