Lan Lu1, Bernadette Erowku1, Gregory R. Lee1, Katherine Dell2,3, Chris A. Flask1,4
1Radiology, Case Western Reserve University, Cleveland, OH, USA; 2Pediatrics, Case Western Reserve University, Cleveland, OH, USA; 3MetroHealth Medical Center, Cleveland, OH, USA; 4Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA
Diffusion MRI applications typically utilize rapid Echo-Planar Imaging (EPI) acquisition techniques. However, EPI techniques are susceptible to off-resonance distortion and eddy current artifacts, especially for high field MRI applications. We have developed a rapid Diffusion Prepared - Fast Imaging with Steady-State Free Precession (DP-FISP) MRI acquisition for a 7T small animal MRI scanner that combines a diffusion preparation scheme with a rapid FISP imaging readout to provide diffusion-weighted images in less than 500 ms and DTI data (7 directions) in less than 1 minute. Herein, DP-FISP results validated in a water phantom and in vivo polycystic rat kidneys.