Peiying Liu1, Jinsoo
Uh1, Michael D. Devous2, Bryon Adinoff3,4,
Hanzhang Lu1
1Advanced
Imaging Research Center, University of Texas Southwestern Medical Center,
Dallas, TX, USA; 2Department of Radiology, University of Texas
Southwestern Medical Center, Dallas, TX, USA; 3Department of
Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA;
4VA North Texas Health Care System, Dallas, TX, USA
Pseudo-continuous Arterial Spin Labeling (PCASL) as a new arterial spin labeling (ASL) technique has shown great promises in terms of sensitivity and practicality. Validation of this technique with a gold-standard method would provide a critical step toward wider applications in neurological and brain mapping studies. Here we first determined the arterial transit times which are important in the quantification of CBF from ASL signals by measuring the time difference between the appearance of Gd-DTPA bolus in the labeling and imaging slices, respectively. We then conducted a validation study of PCASL using a radiotracer-based single photon emission computer tomography (SPECT) method.