Lu-Ping Li1, Tammy Franklin2, Joann Carbray2, Maria Papadopulou-Rosenzweig3, Richard Solomon4, Pottumarthi V. Prasad1
1Radiology / Center for Advanced Imaging, Northshore University Healthsystem, Evanston, IL, USA; 2Radiology / Center for Advanced Imaging, Northshore University Healthsystem, Evanston, IL , USA; 3Radiation Medicine, Northshore University Healthsystem, Evanston, IL , USA; 4Nephrology, University of Vermont, Burlington, VT , USA
Radio-contrast induced nephropathy (CIN) is the 3rd common cause of in-hospital mortality in patients with pre-existing kidney insufficiency. Although iso-osmolal agents are believed to be safer than ionic and high-osmolal agents, the issue remains controversial. Other physical properties such as viscosity may play a significant role in determining risk. Renal hypoxia is known to play a role in the pathophysiology of CIN and BOLD MRI was previously shown to be useful in monitoring the changes in intra-renal oxygenation with iothalamate, an ionic high osmolality agent. Here, we report our preliminary direct comparison between iodixanol, a nonionic iso-osmolal agent and iothalamate.