Danny J. J. Wang1, David S. Liebeskind1, Qing Hao1, Joe X. Qiao2, Rana Fiazv1, Matthias Gunther3,4, Whitney B. Pope2, Samuel Hou2, Lirong Yan1, Jeffrey L. Saver1, Noriko Salamon2, Jeffry R. Alger1,2
1Neurology, UCLA, Los Angeles, CA, USA; 2Radiology, UCLA, Los Angeles, CA, USA; 3Faculty of Physics & Electronics, University of Bremen, Bremen, Germany; 4Fraunhofer MEVIS-Institute for Medical Image Computing, Bremen, Germany
Pseudo-continuous arterial spin labeling (ASL) and dynamic susceptibility contrast enhanced (DSC) perfusion imaging were carried out in 27 cases of acute ischemic stroke. ASL CBF and DSC CBF, Tmax maps provided largely consistent results in delineating hypoperfusion lesions. ASL CBF, nevertheless, was more sensitive than DSC CBF in delineating hyperemic lesions which Tmax and MTT maps were unable to demonstrate. After calibration using CBF in control regions, a strong correlation emerged between mean ASL and DSC CBF values in the penumbral zones defined by Tmax>4s. This study illustrated the potential for combined ASL and DSC perfusion imaging in acute stroke.