1Center for Magnetic Resonance Research, Univ. of Minnesota, Minneapolis, MN, USA; 2Dept. of Orthopedic Surgery, Univ. of Minnesota, Minneapolis, MN, USA
Bovine patellar cartilage plugs with trypsin treatment (n=4) were used to compare various contrast mechanisms, including T2, T1ρ by adiabatic HS1 and HS4 modulation, RAFF (relaxation along a fictitious field), and MT (magnetic transfer). Each of the plugs was scanned twice: before and after trypsin treatments. The control group (n=4) were through the same process except without trypsin treatment. Our results not only depict that adiabatic T1ρ gives rise to high sensitivity to proteoglycan induced change in cartilage, but also indicate it is a robust and artifact-free method.