Paul A. Yushkevich1, Hongzhi Wang1, John Pluta1, Sandhitsu R. Das1, Brian Avants1, Michael Weiner2, Susanne Mueller2, David Wolk3
1PICSL, Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA; 2Department of Radiology, University of California, San Francisco, San Francisco, CA, USA; 3Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
High-resolution T2-weighted MRI has been shown to be a promising modality for imaging the subfields of the hippocampal formation. However, until now, the analysis of this data required tedious manual segmentation. We present a reliable method for automatic segmentation of hippocampal subfields in T2-weighted MRI and apply it to measure group differences in subfield volume and thickness between amnestic MCI patients and controls.