Michael Kwan-Yoe Liem1, Saskia A. J. Lesnik Oberstein2, Maarten J. Versluis1, Joost Haan3, Andrew G. Webb1, Michel D. Ferrari3, Mark A. van Buchem1, Jeroen van der Grond1
1Radiology, Leiden University Medical Center, Leiden, Netherlands; 2Clinical Genetics, Leiden University Medical Center, Leiden, Netherlands; 3Neurology, Leiden University Medical Center, Leiden, Netherlands
In this study we quantified diffuse iron deposition in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), using phase and magnitude imaging on 7 Tesla MRI. Twenty-five CADASIL patients and 15 healthy controls were examined using high resolution T2* imaging on 7 Tesla MRI. Increased phase shift and reduced signal intensity were found in the putamen and caudate nucleus of CADASIL patients which is likely caused by increased diffuse iron accumulation. In the cortex and white matter no signs of increased iron accumulation were found.