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Abstract #0632

Dynamic Magnetic Resonance Multi-Projection Inverse Imaging (Mini) with Isotropic Spatial Resolution

Kevin Wen-Kai Tsai1, Aapo Nummenmaa2, Thomas Witzel2,3, Wei-Tang Chang4, Wei-Jui Kuo5, Fa-Hsuan Lin1,2

1Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan; 2A. A. Martinos Center, Massachusetts General Hospital, Charlestown, MA, USA; 3Harvard-MIT Divisions of Health Sciences & Technique, Charlestown, MA, USA; 4Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan, Taiwan; 5Cognitive Neuropsychology Laboratory, National Yang-Ming University, Taipei, Taiwan, Taiwan


MR inverse imaging (InI) can achieve 100 ms temporal resolution with whole-brain coverage using highly parallel detection at the cost of compromised spatial resolution due to solving ill-posed inverse problems in image reconstruction. Here we propose the multi-projection InI (mInI) method. Using projection data in three orthogonal directions from all RF channels separately can achieve a high temporal resolution without compromising spatial resolution. Results of using mInI to study the hemodynamic responses in human visuomotor system from 12 participants using a 32-channel head coil array at 3T can achieve 100 ms temporal resolution and 4 mm3 isotropic spatial resolution.