Yu-Xiang Ye1, Thomas
Christian Basse-Luesebrink1, Paula Arias2, Thomas Kampf1,
1Department for Experimental Physics 5, University of Wrzburg, Wrzburg, Bavaria, Germany; 2Department of Internal Medicine I, University Hospital Wrzburg; 3Institute for Virology & Immunobiology; 4Institute for Pharmacology & Toxicology, University of Wrzburg; 5MRB Research Center, Magnetic Resonance Bavaria
In acute myocardial infarction (MI) blood monocytes play a key role in wound healing. Non-invasive imaging strategies are required to better understand and translate this knowledge into clinics. We investigated the value of integrating 19F-MRI cell trafficking with 1H-cardiac MRI to monitor an anti-inflammatory therapeutic approach of Atorgastatin in a MI rat model. The combined 19F/1H MRI found reduced myocardial monocyte infiltration and revealed a possible mechanism of action by Atorvastatin. Our platform provides a novel view on tissue injury and its innate immune response after ischemia-reperfusion, and thus contribute to gain new insights of anti-inflammatory therapy in MI.